I-4% yesitofu se-Gentamyclin sulphate
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Isalathiso
Imbonakalo:Le mveliso ayinambala ukuya kumthubi okanye ulwelo oluluhlaza olucacileyo olutyheli.
Isenzo se-Pharmacological:PharmacodynamicGentamycini-antibiotic ye-aminoglycoside ene-antibacterial effect kwiintlobo ze-bacteria ze-gram-negative (ezifana ne-Escherichia coli, i-Klebsiella, i-Proteus, i-Pseudomonas aeruginosa, i-Pasteurella, i-Salmonella, njl.) kunye ne-Staphylococcus aureus (kubandakanywa ne-β-lacingstrains-pro).Uninzi lwe-cocci (i-Streptococcus pyogenes, i-pneumococcus, i-Streptococcus faecalis, njl.), ibhaktheriya ye-anaerobic (i-Bacteroides okanye i-Clostridium), i-Mycobacterium tuberculosis, i-Rickettsia kunye ne-fungi zixhathisa le mveliso.
I-Pharmacokinetics:Ukufunxa kukhawuleza kwaye kugqibelele emva kokutofa nge-intramuscular.Ugxininiso oluphezulu lufikelelwa kwi-0.5 ukuya kwi-1 iyure.I-Bioavailability idlula i-90% yenaliti engaphantsi kwesikhumba okanye kwi-intramuscular.Ikhutshelwa ikakhulu yi-glomerular filtration kunye ne-akhawunti ye-40% ukuya kwi-80% yedosi elawulwayo.Ukupheliswa kwesiqingatha-ubomi emva naliti intramuscular yi 1.8 ukuba 3.3 iiyure amahashe, 2.2 ukuba 2.7 iiyure amathole, 0.5 ukuba 1.5 iiyure izinja neekati, 1 iyure ezinkomeni neehagu, 1 ukuba 2 iiyure imivundla, kunye 2.3 ukuya 3.2 iiyure zegusha, iinyathi, iinkomo neebhokhwe zobisi.
Ukudibana kweziyobisi:
(1) Indibaniselwano yeGentamycin ene-tetracycline kunye ne-erythromycin inokuba nefuthe elichasayo.
(2) Ngokudibanisa ne-cephalosporins, i-dextran, i-diuretics enamandla (njenge-furosemide, njl.), kunye ne-erythromycin, i-ototoxicity yale mveliso inokuphuculwa.
(3) Izihlunu ze-skeletal muscles (ezifana ne-succinylcholine chloride, njl.) okanye iziyobisi ezinolu mphumo zinokuphucula i-neuromuscular blocking effect ye-HUMIRA.
Isenzo kunye nokusetyenziswa
Aminoglycoside antibiotics.Kwi-Gram-negative kunye nosulelo lwe-bacterial positive.
Umthamo kunye nolawulo
(1) I-Ototoxicity.Ihlala ibangela umonakalo we-vestibular endlebeni, enokuthi ibe nzima ngokuqokelelwa kwezidakamizwa ezilawulwa ngokuqhubekayo ngendlela exhomekeke kwidosi.
(2) Ukwaliwa ngamanye amaxesha.Iikati zinovakalelo ngakumbi, rhoqo kunokubangela isicaphucaphu, ukuhlanza, i-salivation kunye ne-ataxia.
(3) Amanani aphezulu angabangela i-neuromuscular conduction blockade.Ukufa ngengozi kaninzi kwenzeka emva kwe-anesthesia jikelele kwiinkqubo zotyando kwizinja kunye neekati, zidibaniswe ne-penicillin ukukhusela usulelo.
(4) Inokubangela i-nephrotoxicity ebuyela umva.
Ukulumkela
(1) IGentamycin inokusetyenziswa ngokudityaniswa ne-β-lactam antibiotics ukunyanga izifo ezinzima, kodwa ayihambelani xa ixutywe kwi-vitro.
(2) Ngokudibanisa ne-penicillin, le mveliso inefuthe le-synergistic kwi-streptococci.
(3) Inokudakumba kokuphefumla kwaye ayifanele itofwe ngomthambo.
(4) I-Antagonism ingenzeka ngokudibanisa ne-tetracycline kunye ne-erythromycin.
(5) Ukudibanisa kunye ne-cephalosporins kunokunyusa i-nephrotoxicity.
Ixesha lokurhoxisa
Ihagu, inkomo kunye neegusha iintsuku ezingama-40.
Ugcino
Itywinwe kwaye igcinwe kwindawo emnyama epholileyo.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.
