Tildidirosin
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Tildidirosin
I-Tildidirosin luhlobo olutsha lwe-semi-synthetic ye-16-membered ring macrolide antibiotics yezilwanyana, ephuma kwi-tylosin.
Isenzo se-Pharmacological
Impembelelo ye-antibacterial ye-Tildidirosin ifana ne-tylosin, kwaye inempembelelo enamandla yokuthintela kwiibhaktheriya ze-Gram-positive kunye nezinye iibhaktheriya ze-Gram-negative.Indlela yokulwa ne-antibacterial ye-Tildidirosin iyafana neye-macrolides.Iyakwazi ukudibanisa kunye ne-50S subunit ye-ribosome yeebhaktheriya ezithintekayo ukuvimbela ukuhlanganiswa kwe-riboprotein peptide chain, ngaloo ndlela ichaphazela ukuhlanganiswa kweeprotheni zebhaktheriya.Ukusebenzisana kwamacandelo amabini e-piperidine ekhethekileyo kwi-Tildidirosin iyahlula indlela yokusebenza kweli chiza kwi-tylosin kunye ne-tilmicosin, apho i-20-piperidine iqondiswe kwi-lumen ukuphazamisa ukukhula kwe-peptides ye-nascent.
Ngenxa yokuba i-tedroxine inamaqela ama-3 asisiseko e-amino, inokwenza iifom ezahlukeneyo zokuhlawuliswa phantsi kweemeko ezahlukeneyo ze-pH.Ubungakanani bentlawulo yinto ephambili yokutshabalalisa i-solubility ye-lipids yebhaktheriya kwaye ingene kwi-membrane yangaphandle ye-Gram-negative bacteria, ngoko ke umsebenzi we-bacteriostatic we-Tildidirosin in vitro uchaphazeleka kakhulu nge-pH.Ngaphantsi kweemeko ze-acidic, iqela le-amino li-protonated, okukhokelela ekunciphiseni komsebenzi we-antibacterial we-tediroxine, ngelixa phantsi kweemeko ze-alkaline, inomsebenzi onamandla we-antibacterial.
I-Macrolides inqanda ukukhutshwa kwe-cytokines ye-proinflammatory, umsebenzi we-phospholipase, kunye nokukhululwa kwe-leukotriene, kwaye ibe nemiphumo yokuchasana nokuvuvukala kwi-macrophages kunye neutrophils.I-Tediroxine inciphisa abalamli abavuthayo abaveliswa ngexesha elithile lokukrala okanye iimpendulo zoxinzelelo.
I-antibacterial spectrum
I-Tildipirosin iyasebenza ngokuchasene neebhaktheriya ze-pathogenic ezibangela izifo zokuphefumla kwiihagu kunye neenkomo (ezifana nePasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp.) , kunye nomsebenzi we-antibacterial ngokumelene ne-intestinal Escherichia coli yayingcono kune-tylosin kunye ne-tilmicosin.Ikwanovakalelo kwiintlobo ezithile ze-mycoplasma, i-spirochetes, i-brucella, njl. Uphononongo lubonise ukuba i-tediroxine inefuthe elinamandla le-bacteriostatic kwi-Haemophilus parasuis kunye ne-Bordetella bronchiseptica kune-florfenicol, kodwa isiphumo esibuthathaka se-bacteriostatic kwi-Actinobacillus pleuropneumoniae kunye ne-Pasteurella multocida.I-Tildipirosin ibulala iintsholongwane kwezinye iibhaktiriya (ezifana ne-Haemophilus parasuis kunye ne-Actinobacillus pleuropneumoniae), ngelixa ingakumbi i-bacteriostatic kwezinye iibhaktiriya (ezifana ne-Pasteurella multocida).Kwiibhaktheriya zamathumbu, kunye nokuncipha kwexabiso le-pH (ukusuka kwi-7.3 ukuya kwi-6.7), i-MIC ye-Tildidirosin yanda, umzekelo, i-MIC ye-Tildipirosin ngokumelene ne-Salmonella Enteritidis kunye ne-Escherichia coli inokunyuka ukusuka kwi-2 ~ 8ug / m ukuya kwi-64 ~ 256ug / mL. .Ke ngoko, isiphumo sotshintsho lwe-pH kwi-vivo kufuneka siqwalaselwe xa uqhuba uvavanyo lwe-antibacterial ye-Tildidirosin kwi-vivo.Ukongezelela, i-MIC ye-Tildidirosin ngokuchasene neentlobo eziqhelekileyo ze-Pasteurella multocida yayingu-0.5ug / mL kwi-serum, eyayiyi-0.25 ngamaxesha angaphantsi kwe-in vitro, enokuthi ihambelane ne-serum effect.
I-Enterococcus-Streptococcus kwinkomo zobisi ixhathisa kakhulu kwi tediroxine.I-Tildipirosin ayinaluvelwano kwi-Pasteurella multocida kunye ne-Mannheimia haemolyticus ethwele imfuzo eguqukayo.Ngokufanayo, iintlobo ze-M. bovis eziguquguqukayo zofuzo ziyaxhathisa kwi-macrolide antibiotics kuquka i-Tildidirosin.Iintlobo ezithile ze-Haemophilus parasuis nazo zifunyenwe zikwazi ukumelana ne-tediroxine ngokwendalo.I-Mycoplasma bovis inokukhawuleza ifumane ukuchasana ne-Tildidirosin, kodwa ngenxa yokukhula okucothayo kwe-Mycoplasma, ukuvavanywa kwe-in vitro ukuchaphazeleka kweziyobisi kunokulibazisa unyango.Izifundo zibonise ukuba i-domain II (i-nucleotide 748) kunye ne-domain V (Ukuguqulwa kwe-nucleotides 2059 kunye ne-2060) ihambelana nokunyuka kokuchasana kwe-macrolides.Ke ngoko, ukuchaphazeleka kweM. bovis kumachiza e-macrolide kunokufunyanwa ngokukhawuleza ngovavanyo lwemolekyuli yolu tshintsho.
Umxholo
≥ 98%
Inkcazo
Umgangatho wenkampani
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.
