Tillpirosin
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Tillpirosin
I-Tillipfirosin luhlobo olutsha lwe-syntichetic ye-swiaticy 16 ye-memprolide ye-sucpilide ye-antibiotic yezilwanyana, esungulo lweTylosin.
Inketho ye-Pharmacological
Iziphumo ezidibeneyo zeTillipiron ziyafana neyo le nto yeTylosin, kwaye inesiphumo esiqinileyo sebacteria kunye ne-GRAM-engalunganga. Indlela ye-tiltickirosin ye-tillipirosin iyafana neyabantu baseMacrollis. Inokudibanisa kunye ne-50s subnit ye-ribome ye-bacteria ebuthathaka ukuba ithintele i-syntheli ye-riboprotein ye-riboprotetin peptide, ngaloo ndlela ichaphazela i-synthesins yeeproteri zentsholongwane. Ukudibana kwezinto ezimbini zePipersine ngokwahlukileyo kwi-Tillippin ukwahlulahlula inyathelo lesenzo ukusuka eTylosin naseTilicosin, apho i-20-piperidine ibhekiswe kwi-lumen yokuphazamisa ukukhula kwe-noscent.
Kuba i-tidiroxine inamaqela ama-3 asisiseko, inokwenza iifom ezahlukeneyo ezihlawulwe phantsi kweemeko ze-ps ezahlukeneyo. Isixa sentlawulo yinto ephambili yokutshabalalisa i-smoubil lipids kwaye ingene kwi-wicteria engaphandle ye-GRAM, ngoko ke umsebenzi we-tiltipiatin ochaphazeleka kakhulu kwi-vitros ichaphazeleke kakhulu yi-vitro. Phantsi kweemeko ze-ACIIIC, iqela le-Amino lidluliselwa, kubangela ukwehla komsebenzi we-tedibacterine, ngelixa uphantsi kweemeko ze-alkaline, inomsebenzi owomeleleyo.
I-MacCrororororororollide ithintele ukufihlakala kwe-proinfamines cytokines, i-phospholipase imisebenzi, kunye ne-leukotlene yokukhutshwa, kwaye ineziphumo ze-inti-insulmatory kwi-macrophoges kunye ne-neutrophils. I-Tediroxine inciphisa ii-Deamgrayers eziveliswe ngexesha lokukhuthaza okanye iimpendulo zoxinzelelo.
I-Antibacterium
I-Tillipirosin isebenza ngokuchasene neBacteriac Bacteriac Bacteria enokubangela izifo zokuphefumla kwiihagu kunye ne-pasteurea mlchiseptica, i-ardetella birsoonis, i-amemobilis ye-tilchisin yayiphezulu kunelo I-TILCEMIOSION, kunye nomsebenzi we-antibacterial nxamnye ne-Esstinal Escherichial Coli yayingcono kune-chalosin kunye ne-tilmicosin. Ikwanobuthathaka kwezinye izifundo ze-mycoplasma, i-spirochete, i-Brucella, njl.njl. Isiphumo se-tirteenic sine-binsiostal kunye ne-bordeella ye-binchigulatic, kodwa i-becteriostatic ye-binchiostia ye-auropneumonia kunye ne-pasteurella multocida. I-Tillipirosin yi-bactericidal kwezinye iintsholongwane (ezinje nge-haemophilis parasuis kunye ne-artinobacilsus ye-couropneumoniade), ngelixa ikakhulu i-bactetiostatic ye-bacteria (njenge-pacteria (njenge-pasterea multocida). Intsholongwane yamathumbu, ngokuhla kwexabiso le-pH (ukusuka kwi-7.7. Ke ngoko, ifuthe le-PH itshintsha e-Vivo kufuneka ithathelwe ingqalelo xa iqhuba i-Vivocionacracirosin. Ukongeza, uMic of Tillipirosin nxamnye nobunzima obuqhelekileyo be-pasteurella multocida i-0.5ug / ML kwi-vitro, enokuhambelana ne-vitro, enokuthi inxulumene nefuthe.
I-Enterococcus-streptococcus kwiimazi zobisi zixhathise kakhulu kwi-tideroxine. I-Thilipirosin ayikhathalelanga kwi-pasteurea multocidada kunye ne-mannheimia haemolyticato ithwala imfuyo. Ngokukwanjalo, ngokwemvelo kwe-gener ye-M. I-Bovis ayinyangeki kwi-sucrolitics kubandakanya i-tilpirosin. Imingxunya ethile ye-haemophilis parasuis nayo yafunyanwa ixhathise ngokwemvelo kwi-tideroxine. I-Mycoplasma Bovis inokufumana ngokukhawuleza ukuchasana ne-tillpirosin, kodwa ngenxa yokukhula kancinci kwe-Mycoplasma, kuvavanyo lwe-VITROCHECHECHEECEECMECAPS olunokulibazisa unyango. Izifundo zibonakalise ukuba i-domain II (iNukcleotide 748) kunye ne-Domain v (iguquko kwi-nuclotides 2059 kunye ne-2060) zinxulunyaniswa nokunganyangeki okwandisiweyo kwe-succorollis. Ke ngoko, ukusityaka kweM. I-Bovis kwiziyobisi zemali zinokufunyanwa ngokukhawuleza kukuvavanywa kwemolekyuli kule ngca.
Umxholo
≥ 98%
Ukucaciswa
Umgangatho wenkampani
I-Hebei Veyolong Pharmaceutical Co., i-LTD, ibekwe kwiSixeko saseShijiazhuang, kwiPhondo laseHebei, iChina, ecaleni kwengxowa ye-Beijing. Uyishishini elikhulu eliqinisekisiweyo le-GMP le-GEMP ye-GEMP, ene-R & D, ukuvelisa kunye nentengiso ye-Veterinal Apis, amalungiselelo, i-PREPEDED yezongezo. Njengeziko lobugcisa lePhondo, iVeyong iseke inkqubo ye-R & D yeS System yeZiyobisi eziNtsha zeZilwanyana, kwaye zisekelezwe kwishishini lezonyango lwezilwanyana, kukho iingcali ezingama-65 zezobugcisa. IVeyong ineziseko zambini zemveliso: Shijiazhuang kunye ne-Shijiazduang Isiseko esinendawo ye-78,706 M2, i-APPINECTINE YEMIQATHANGO YOKUGQIBELA, I-APIALITINE YOKUGQIBELA I-IYIMATION, i-APIALITCINE YEMIQATHANGO YOKUGQIBELA, INDAWO YOKUGQIBELA, I-PREPE, Izitshabalalisi kunye nentsholongwane, i-ECT. IVeyong ibonelela nge-APIs, amalungiselelo angaphezu kwe-100 yeelebheli, kunye nenkonzo ye-OEM ye-ODM.
IVeyong inamathela ngokubaluleke kakhulu kulawulo lwe-EHS (engqongileyo, iMpilo noKhuseleko), kwaye bafumana i-ISO14001 kunye nezatifikethi ze-OHSAs18001. IVeyong idweliswe kumashishini asahlumayo kwiPhondo kwiPhondo laseHebei kwaye unokuqinisekisa ukuqhubeka kweemveliso.
IVeyong iseke inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, iSiqinisekiso se-China E-Australia APVMA GMP IVeyong ineqela elinobuchule, ukuthengisa kunye nenkonzo yezobuchwephesha, inkampani yethu ifumene ukuthembela kunye nenkxaso yabathengi abaninzi ngoMgangatho wemveliso ebalaseleyo, inkonzo yasemva kwentengiso kunye nezenzululwazi. IVeyong yenze intsebenziswano yexesha elide yamashishini amashishini amaninzi amayeza e-EURRERMEEDICATION ezikhutshelwe ngaphandle eYurophu, uMzantsi Merika, eMbindi Mpuma, e-Afrika, iAfrika, njl njl.
