10% Isitofu se-Enrofloxacin
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Ividiyo
Isenzo se-Pharmacological
I-Enrofloxacin yi-agent ebanzi ye-bactericidal yezilwanyana ze-fluoroquinolone.KuEscherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's sepsis Bacteria, Staphylococcus aureus, Mycoplasmas, achlamydia, etc. kunye neStreptococcus, kunye neziphumo ezibuthathaka kwiibhaktheriya ze-anaerobic.Inefuthe elicacileyo le-antibacterial kwiibhaktheriya ezibuthathaka.Inkqubo yesenzo se-antibacterial yale mveliso kukuthintela i-bacterial DNA gyrase kwaye iphazamise ukuphindaphinda kwe-DNA ye-bacterial, ukushicilela kunye nokulungiswa kunye nokudibanisa kwakhona.Ibhaktiriya ayikwazi ukukhula kwaye iphinde ivelise njengesiqhelo kwaye ife.
Pharmacokinetics
10% Isitofu se-Enrofloxacinifunxwa ngokukhawuleza nangokupheleleyo ngenaliti ye-intramuscular.Ibioavailability yalemveliso yi 91.9% yeehagu kunye ne 82% yeenkomo zobisi.Isasazwa ngokubanzi kwizilwanyana kwaye inokungena kakuhle kwizicubu.Ngaphandle kwe-cerebrospinal fluid, ukuxinwa kweziyobisi phantse kuzo zonke izihlunu kuphezulu kunoko kwiplasma.I-metabolism yesibindi ikakhulu ukususa iqela le-ethyl le-7-piperazine ring ukuvelisa i-ciprofloxacin, ilandelwa yi-oxidation kunye ne-glucuronic acid ebophayo.Ininzi ikhutshwe ngeentso (ngokusebenzisa i-renal tubular secretion kunye ne-glomerular filtration), kwaye i-15% ~ 50% ikhutshwe kumchamo kwindlela yayo yokuqala.Ukupheliswa kobomi besiqingatha kuyahluka kakhulu phakathi kweentlobo ezahlukeneyo zezilwanyana kunye neendlela ezahlukeneyo zolawulo.Ukuphelisa isiqingatha sobomi emva kokutofa kwe-intramuscular yi-5.9 yeeyure zeenkomo, iiyure eziyi-9.9 zamahashe, iiyure ezi-1.5 ukuya kwi-4.5 kwiigusha, kunye neeyure ezi-4.6 kwiihagu.
Ukusebenzisana
(1)Isitofu se-10% se-Enrofloxacinisetyenziswe ngokudibeneyo kunye ne-aminoglycosides okanye i-penicillin ebanzi, enefuthe le-synergistic.
(2) I-ion zetsimbi ezinzima ezifana neCa2 +, Mg2 +, Fe3 + kunye ne-Al3 + zinokutshiza le mveliso kwaye zichaphazele ukufunxa.
(3) Xa zidityaniswe ne-theophylline kunye ne-caffeine, inokunciphisa izinga lokubopha iprotheni yeplasma, inyuse ngokungaqhelekanga ukuxinana kwe-theophylline kunye ne-caffeine egazini, kwaye ibangele iimpawu zetyhefu ye-theophylline.
(4) Le mveliso inefuthe lokuthintela i-enzyme yeziyobisi zesibindi, ezinokunciphisa izinga lokucocwa kweziyobisi ezixutywe kakhulu esibindini kwaye zandise ukuxinwa kweziyobisi zegazi.
Umsebenzi kunye nokusetyenziswa
I-Fluoroquinolone antibacterial drugs.Isetyenziselwa izifo zebhaktheriya kunye nosulelo lwe-mycoplasma kwimfuyo kunye neenkukhu
Umthamo kunye nolawulo
Inaliti ye-Intramuscular: idosi enye, ubunzima bomzimba obu-1kg, 0.025ml yeenkomo, iigusha, neehagu;0.025 ~ 0.05ml izinja, iikati, kunye nemivundla.Sebenzisa i-1 ukuya ku-2 amaxesha ngosuku ngeentsuku ezi-2 ukuya kwezi-3.
Ukusabela kakubi
(1) Ukutshatyalaliswa kwe-cartilage kwizilwanyana ezincinci, ezichaphazela ukuphuhliswa kwamathambo kunye nokubangela i-claudication kunye nentlungu.
(2) Iimpendulo zenkqubo yokugaya ziquka ukuhlanza, ukulahlekelwa ngumdla, kunye nohudo.
(3) Ukuphendula kwesikhumba kubandakanya i-erythema, itching, urticaria kunye ne-photosensitivity.
(4) Ukwaliwa, i-ataxia, kunye nokuxhuzula kubonwa ngamaxesha athile kwizinja kunye neekati.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.
