20% Albendazole Granule
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I-Pharmacology
I-Albendazole yi-benzimidazole ephuma kwi-benzimidazole, enokuthi ifakwe ngokukhawuleza emzimbeni kwi-sulfoxide, i-sulfone alcohol kunye ne-2-aminosulfone alcohol.Ithintela ngokukhethayo kwaye ngokungenakuguquleka i-polymerization ye-cytoplasmic microtubule system ye-parasite's intestinal wall cell for intestinal nematodes, enokuthintela ukufunxwa kunye nokufunxwa kweentlobo ngeentlobo zezondlo kunye ne-glucose, ekhokelela ekuphelelweni kwe-glycogen engapheliyo kwizinambuzane, kunye ne-inhibits. I-fumarate reductase Inkqubo ithintela ukuveliswa kwe-adenosine triphosphate kwaye ithintela ukuphila kunye nokuzala kombungu.Ngokufanayo ne-mebendazole, le mveliso inokubangela ukuwohloka kwe-cytoplasmic microtubules yeeseli zamathumbu ombungu, kwaye ibophelele kwi-tubulin yayo, ibangele ukuvaleka kokuthuthwa kwe-intracellular, kubangele ukuqokelelana kweegranules ze-Golgi endocrine, ukuchithwa kancinci kwe-cytoplasmic, kunye nokuwohloka ngokupheleleyo. iiseli.Ibangela ukufa kombungu.20% Albendazole granuleangawabulala ngokupheleleyo amaqanda eentshulube kunye namaqanda omtshulube kwaye ngokuyinxenye abulale amaqanda entshulube.Ukongeza ekubulaleni nasekugxotheni iinematodes ezahlukeneyo ezizifunxi-gazi kwizilwanyana, ikwaneziphumo ezicacileyo zokubulala kunye nokugxotha kwi tapeworms kunye ne cysticercus.
I-Toxicology
Uvavanyo lwe-Toxicological lubonisa ukuba le mveliso inetyhefu ephantsi kwaye ikhuselekile.I-LD50 yomlomo yeempuku inkulu kune-800mg/kg, kwaye idosi ephezulu enyamezelekayo kwizinja ingaphezulu kwe-400mg/kg.Eli chiza alinampembelelo kumsebenzi wokuzala weempuku zamadoda, kwaye alinayo impembelelo ye-teratogenic kwiigundane ezibhinqileyo.Ukufunxa iFetal kusengenzeka xa idosi enkulu [30 mg/(㎏··day)] igalelwa kwiimpuku ezimazi nakwimivundla.Kunye nokukhubazeka kwamathambo.
Ukusetyenziswa kunye nomthamo
Ngokusekelwe kwi-albendazole.Ukulawulwa ngomlomo: kanye, 25 ~ 50mg / kg ubunzima bomzimba.Okanye landela icebiso likagqirha.
Iimpendulo Ezibi
(1) xa izinja zinikwa i-50 mg / kg kabini ngosuku, ngokuthe ngcembe zaziba ne-anorexia
(2) Ukusetyenziswa kwe-albendazole ekukhulelweni kokuqala kunokuhamba kunye ne-teratogenicity kunye ne-embryotoxicity.
Phawula
Izilwanyana kufuneka zilumke kwiintsuku zokuqala ezingama-45 emva kokukhulelwa
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.
