250mg Triclabendazole Bolus
Izenzo ze-Pharmacological
I-Pharmacodynamics Triclobendazole yeyodidi lwe-benzimidazole yamachiza, isetyenziselwa ngokukodwa ukuxhathisa i-Fasciola hepatica, kwaye inesiphumo esicacileyo sokubulala kwi-Fasciola hepatica yobudala obahlukeneyo.iyeza lefluke.Emva kokuba ichiza lifunxwe, liphazamisa isakhiwo se-microtubule kunye nomsebenzi we-parasite, Inqanda ukukhululwa kwe-parasite hydrolytic proteases.Isiphumo se-triclobendazole kwiintshulube siyahluka ngokugxininiswa, njengabantu abadala kwiindawo eziphantsi (1 ~ 3μg/ml)
Ichiza lisahlala kwiiyure ze-24, kwaye umsebenzi uyancipha kakhulu kwi-concentration ephezulu (10-25μg / ml) kwiiyure ze-24;i-concentration ephezulu ye-25-50μg / ml ivimbela ngokupheleleyo iiyure ezingama-24.Kodwa uvakalelo ngakumbi kwiintshulube.Kwi-10 μg / ml, yonke imisebenzi yeeyure ezingama-24 yayivinjelwe.
Pharmacokinetics
I-bioavailability ye-triclobendazole iphezulu.Emva kokulawulwa komlomo we-10 mg / kg ubunzima bomzimba kwiibhokhwe kunye neegusha, iyeza le-plasma ephezulu yafikelela kwi-15 μg / ml kwiiyure ezingama-24 ukuya kwii-36, kwaye amanqanaba egazi e-triclobendazole kunye ne-metabolites yayo yayiphezulu.Ixabiso eliphezulu leyeza liyi-5 ukuya kumaxesha angama-20 enye i-benzimidazole anthelmintics, kunye nokupheliswa kwesiqingatha sobomi malunga neeyure ezingama-22.I-Triclobendazole i-oxidized kakhulu kwiigusha kunye neempuku kwi-sulfone kunye ne-sulfoxide derivatives, ebophelela kwi-albumin kwaye iqhubeke kwi-plasma ngaphezu kweentsuku ze-7.Uxinzelelo oluphezulu lweplasma kunye nokubophelela kwi-albumin ye-plasma kubonakala kuhambelana nexesha elide lesenzo se-antifascioli.Emva kweentsuku ezili-10 zokulawulwa kweziyobisi kwiigusha, malunga ne-95% yechiza likhutshelwa kwilindle, i-2% ikhutshelwa kumchamo, kwaye ngaphantsi kwe-1% ikhutshwe ebisi.
Izenzo kunye nokusetyenziswa
Benzimidazole anti-fasciola ichiza.Isetyenziswa ikakhulu kuthintelo kunye nonyango lwe Fasciola hepatica usulelo kwiinkomo neegusha.
Ukusabela kakubi
Akukho ziphumo zibi ziye zabonwa xa zisetyenziswa ngokungqinelana nokusetyenziswa okumiselweyo kunye nedosi
Ukulumkela
(1) Ukhubazekile ngexesha lokuvelisa ubisi.
(2) Inetyhefu enkulu ekulobeni, kwaye inkonkxa yeziyobisi eshiyekileyo ayifanele ingcolise umthombo wamanzi.
(3) Abantu abangadibaniyo namayeza kufuneka bakuphephe ukudibana ngqo nolusu kunye nokuphefumla umoya xa bewasebenzisa, banxibe iiglavu xa bethatha amayeza, kwaye bakwalele ukutya, ukusela kunye nokutshaya.
(4) Hlamba izandla emva kokufaka isicelo
Ixesha lokurhoxisa
Iintsuku ezingama-56 zeenkomo neegusha
Ugcino
Gcina kwindawo engaphantsi kwe-30 ℃.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.