0.2% IVERMECTIN DRENCH
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Isenzo se-Pharmacological
Ivermectinubukhulu becala inesiphumo esihle se-anthelmintic kwi-nematodes kunye ne-arthropods yomhlaba kwi-vivo.Indlela yayo ye-anthelmintic kukukhuthaza ukukhululwa kwe-γ-aminobutyric acid (GABA) kwi-presynaptic neurons, ngaloo ndlela ivula i-GABA-mediated chloride channels.I-Ivermectin iphinda ikhethe kunye nobudlelwane obuphezulu be-glutamate-mediated chloride channels ezikufutshane neendawo ze-GABA-mediated kwi-invertebrate nerve kunye neeseli ze-muscle, ngaloo ndlela iphazamise ukuhanjiswa kwesignali phakathi kwemisipha ye-neuromuscular kunye nokuphumla kunye nokukhubazeka kwe-parasite, okubangela ukufa kwe-parasite okanye ukuxoshwa kwi-parasite. umzimba.I-interneurons evimbelayo kunye ne-motoneurons evuselelayo ye-C. elegans ziindawo zabo zesenzo, ngelixa indawo yesenzo se-arthropods yi-neuromuscular junction.Ikwasebenza ukulwa nearthropods, njengeempethu, iintwala kunye neentwala.abadala iCoronaria dentata kunye nezifunxi-gazi ezingekavuthwa ezihagwini, ikwasebenza ngokugqithisileyo kwiTrichinella spiralis emathunjini (engasebenziyo kwi-intramuscular Trichinella spiralis), kwaye inefuthe elilungileyo lokulawula iintwala zegazi lehagu kunye neSarcoptes scabiei.Ayisebenzi kwi-trematodes kunye ne-tapeworms.
Pharmacokinetics
I-pharmacokinetics yeivermectinziyahluka ngokuphawulekayo ngokuxhomekeke kuhlobo lwesilwanyana, uhlobo lwedosi, kunye nendlela yolawulo.I-bioavailability ye-injection ye-subcutaneous iphezulu kunokulawulwa komlomo, kodwa ukulawulwa komlomo kufakwe ngokukhawuleza kune-injection subcutaneous.Emva kokufunxa, inokusasazwa kakuhle kwizicubu ezininzi, kodwa akulula ukungena kwi-cerebrospinal fluid.Umthamo obonakalayo wokusabalalisa kwiigusha kunye neehagu yi-4.6 kunye ne-4 L / kg, ngokulandelanayo.Inobomi obude besiqingatha sezilwanyana kwizilwanyana ezininzi, i-2 ukuya kwi-7 kunye neentsuku ze-0.5 kwiigusha neehagu, ngokulandelelanayo.Le mveliso ye-metabolized esibindini, ikakhulu i-hydroxylated kwiigusha, kwaye ikakhulu i-methylated kwiihagu.Ininzi ikhutshwe kwi-feces kwaye ngaphantsi kwe-5% ikhutshwe ingatshintshi okanye njenge-metabolites kumchamo.Kumadama okuncancisa, i-5% yethamo ikhutshelwa ebisini.
Ukusebenzisana kweziyobisi
Ukusetyenziswa kunye ne-diethylcarbamazine kunokuvelisa i-encephalopathy enzima okanye ebulalayo.
Isenzo kunye nokusetyenziswa
Macrolide antiparasite amachiza.Isetyenziselwa ukulawula i-nematode, i-acariasis kunye nezifo zezinambuzane ezixhamlayo kwiigusha neehagu.
Umthamo kunye nolawulo
Oral: idosi enye, i-0.1 ml yeegusha kunye ne-0.15 ml yeehagu nge-1 kg yobunzima bomzimba.
Ukusabela kakubi
Akukho ziphumo zibi ziye zabonwa xa zisetyenziswa ngokwenkqubo echaziweyo kunye nethamo.
Ukulumkela
(1)Ayichaswa ngexesha lokuncancisa.
(2) Ifanele isetyenziswe ngononophelo kwiimazi kwiintsuku zokuqala ezingama-45 zokumitha.
(3) Ivermectin shrimp, intlanzi kunye nezinto eziphilayo zasemanzini zinetyhefu kakhulu, kwaye ukupakishwa kunye nezikhongozeli zamachiza ashiyekileyo akufuneki zingcolise imithombo yamanzi.
Ixesha lokurhoxisa: Iigusha ezingama-35 kunye neentsuku ezingama-28 kwiihagu.
Ixesha lokurhoxisa
Iigusha ezingama-35 kunye neentsuku ezingama-28 kwiihagu.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasekwa kwi-2002, ehlala kwisiXeko saseShijiazhuang, kwiPhondo laseHebei, eChina, ecaleni kwe-Capital Beijing.Ulishishini elikhulu leyeza lezilwanyana eliqinisekisiweyo le-GMP, eline-R&D, imveliso kunye nokuthengiswa kwee-APIs zonyango lwezilwanyana, amalungiselelo, ukutya okuxutywe kwangaphambili kunye nezongezo zokutya.NjengeZiko lobuGcisa lePhondo, iVeyong iye yaseka inkqubo yeR&D ehlaziyiweyo yeyeza elitsha lezilwanyana, kwaye lishishini elaziwa kuzwelonke leteknoloji esekelwe kunyango lwezilwanyana, kukho iingcali zobugcisa ezingama-65.I-Veyong ineziseko ezimbini zokuvelisa: i-Shijiazhuang kunye ne-Ordos, apho isiseko se-Shijiazhuang sihlanganisa indawo ye-78,706 m2, kunye neemveliso ze-API ze-13 ezibandakanya i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kunye ne-11, i-injection oral solutions, i-injection oral solutions. , i-premix, i-bolus, i-pesticides kunye ne-disinfectant, njl.IVeyong ibonelela ngee-APIs, ngaphezulu kwe-100 yamalungiselelo eleyibhile, kunye nenkonzo ye-OEM & ODM.
I-Veyong ibona ukubaluleka okukhulu kulawulo lwenkqubo ye-EHS(Environment, Health & Safety), kwaye ifumene i-ISO14001 kunye nezatifikethi ze-OHSAS18001.I-Veyong idweliswe kumashishini amashishini asakhasayo anobuchule kwiPhondo laseHebei kwaye inokuqinisekisa ukubonelela ngokuqhubekayo kweemveliso.
I-Veyong yaseka inkqubo epheleleyo yolawulo lomgangatho, yafumana isatifikethi se-ISO9001, isatifikethi se-GMP sase-China, isiqinisekiso se-APVMA se-GMP sase-Australia, isatifikethi se-GMP sase-Ethiopia, isatifikethi se-Ivermectin CEP, kwaye siphumelele ukuhlolwa kwe-US FDA.I-Veyong ineqela lobuchwephesha lobhaliso, intengiso kunye nenkonzo yobugcisa, inkampani yethu ifumene ukuthembela kunye nenkxaso kubathengi abaninzi ngomgangatho wemveliso ogqwesileyo, umgangatho ophezulu wokuthengisa kwangaphambili kunye nenkonzo yasemva kokuthengisa, ulawulo olunzulu kunye nolwenzululwazi.I-Veyong yenze intsebenziswano yexesha elide kunye namashishini amaninzi amachiza ezilwanyana awaziwayo ngamazwe ngamazwe kunye neemveliso ezithunyelwa eYurophu, eMzantsi Melika, kuMbindi Mpuma, e-Afrika, e-Asia, njl. ngaphezu kwamazwe angama-60 kunye nemimandla.
